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Testing the Epilepsy Drug Perampanel to Prevent Seizures After Cardiac Arrest Resuscitation

Testing the Epilepsy Drug Perampanel to Prevent Seizures After Cardiac Arrest Resuscitation Principal Investigator: Dr. Edilberto Amorim​ Condition: Seizures following cardiac arrest resuscitation Research Description: More than 350,000 Americans have a cardiac arrest...

Enhancing Treatment Response in Recurrent/Metastatic Osteosarcoma with Hydroxychloroquine

Enhancing Treatment Response in Recurrent/Metastatic Osteosarcoma with Hydroxychloroquine Principal Investigator: Dr. Nancy Gordon​ Disease: Osteosarcoma Research Description: Osteosarcoma (OS) is an orphan disease affecting approximately 400 children and adolescents...

Repurposing the Blood Pressure Drug Minoxidil for the Treatment of Recurrent Chemo-Resistant Ovarian and Other Gynecological Cancers

Repurposing the Blood Pressure Drug Minoxidil for the Treatment of Recurrent Chemo-Resistant Ovarian and Other Gynecological Cancers Principal Investigator: Dr. Margaret Liotta Disease: Ovarian cancer Research Description: Epithelial ovarian cancer is the most lethal...


Repurposing the Antiviral Drug Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss

Repurposing the Antiviral Drug Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss Principal Investigator: Dr. Joseph Rower​​ Disease: Hearing loss Research Description: Almost 400 children die each year from congenital cytomegalovirus (cCMV) infections, and...


Treating a Group of Rare Blood Cancers, Myeloproliferative Neoplasms, with N-Acetylcysteine

Treating a Group of Rare Blood Cancers, Myeloproliferative Neoplasms, with N-Acetylcysteine Principal Investigator: Dr. Angela Fleischman​ Disease: Myeloproliferative neoplasms: Polycythemia vera, essential thrombocythemia and myelofibrosis Research Description:...


Repurposing a Blood Cancer Drug to Treat an Immune Disorder (HLH) in Children

Repurposing a Blood Cancer Drug to Treat an Immune Disorder (HLH) in Children Principal Investigator: Dr. Kim Nichols Disease: Hemophagocytic Lymphohistiocytosis Research Description: Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly understood disorder of...


A Novel Combination of Generic Chemotherapy Drugs to Treat Brain Cancer

A Novel Combination of Generic Chemotherapy Drugs to Treat Brain Cancer Principal Investigators: Dr. Bakhos Tannous, Dr. Isabel Arrillaga-Romany, Dr. Mathilde Kouwenhoven, Dr. Myra Van Linde   Disease: Glioblastoma Research Description: Glioblastomas (GBMs) are...


The THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa

The THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa Principal Investigator: Dr. Majdi Osman, Dr. Shrish Budree​ Disease: Severe and Moderate Pediatric Malnutrition Research Description: Globally,...