Current Research

38 Active Trials at 32 Institutions in 29 Diseases in 8 Countries

Researchers work on current repurposing research projects We support investigator-initiated repurposing research projects in any unsolved disease including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. We support projects from accredited academic and nonprofit research institutions and large group medical practices located anywhere in the world. Our Impact Awards support early-stage companies bringing a repurposed treatment to market.

We take an impact philanthropy approach that prioritizes patient when selecting repurposing research projects. We support both philanthropic projects, which have little or no commercial value but have critical value to patients, as well as commercial projects, which industry may bring to regulatory approval and then to market. Our proof-of-concept funding of repurposing projects allows researchers and clinicians to leverage positive data into follow-on funding.

Our current projects were selected through a two-stage submission process. Applicants submit a brief proposal submissions usually followed by full grant applications. Project proposals are reviewed by an external, volunteer Grant Review Committee which represents academia, industry, clinicians and the patient voice. The committee helps staff and the Science Advisory Board select the strongest projects. Our customized approach allows donors to be as involved in the entire process as desired.

The diversity of our current projects reflects our disease-agnostic, patient-first approach:

more than 75% adult, less than 25% pediatric
more than 85% clinical, less than 15% pre-clinical
more than 75% drug, less than 25% device or other
more than 75% US-based, less than 25% outside of the US

Current Repurposing Research Projects

DISEASE AREA	INSTITUTION	LEAD RESEARCHER	PROJECT NAME	TYPE	OTHER	STATUS
Diabetes	Massachusetts General Hospital	Dr. Faustman	Repurposing a Vaccine for Type I Diabetes	Vaccine	Adult	In Process
Diabetic Ophthalmology	Northwestern University	Dr. Basti	Treating Cataracts in Diabetic Patients Using a Surgical Device	Device	Adult	In Process
Ear Nose Throat	House Ear Institute	Dr. Derebery	Reducing vertigo and hearing loss in Meniere’s disease by repurposing a common allergy drug	Drug	Adult	In Process
Ear Nose Throat	ibs Granada	Dr. Gallego-Martinez	Searching for Pharmacogenetic Targets in Meniere’s Disease Patients	Drug	Pre-Clinical	Started 2022
Ear Nose Throat	Stanford Medicine	Dr. Grimes; Dr. Santa Maria	Modulating inner ear fluid regulation to treat Meniere’s disease	Drug	Pre-Clinical	In Process
Ear Nose Throat	The Feinstein Institutes for Medical Research	Dr. Pathak	Investigating the effects of repurposed diuretic, steroid and immunosuppressive drugs in Meniere’s disease	Drug	Pre-Clinical	In Process
Ear Nose Throat	Medical University of South Carolina	Dr. Rizk	Assessing the efficacy of an antidepressant for improving vertigo attacks in Meniere’s disease	Drug	Adult	In Process
Ear Nose Throat	Hospital of the Ludwig-Maximilians University, Munich	Dr. Strupp	Combining a vertigo drug with a Parkinson’s disease drug to treat the inner ear disorder, Meniere’s disease	Drug	Adult	In Process
Ear Nose Throat	Dent Neurologic Institute	Dr. Zhang	Combining an anti-epileptic drug with an anti-anxiety drug to treat the inner ear disorder Meniere’s disease	Drug	Adult	In Process
Ear Nose Throat	Hospital of the Ludwig-Maximilians University, Munich	Dr. Zwergal	Identifying a Potential Biomarker and Repurposed Migraine Treatment in Meniere’s disease	Drug	Adult	Started 2022
Ear Nose Throat/Infectious Disease	University College Hospital Ibadan	Dr. Jatto	Repurposing a Widely Available Antiseptic in Pediatric Chronic Ear Infections in Nigeria	Drug	Pediatric	Started 2022
Ear Nose Throat/Infectious Disease/Rare	University of Utah	Dr. Rower	Repurposing the Antiviral Drug Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss	Drug	Pediatric	In Process
Immune Disorder/Rare	Cincinnati Children's Hospital Medical Center	Dr. Abonia	Repurposing a Rare Disease Treatment for the Immune Disorder Eosinophilic Esophagitis	Drug	Adult	Started 2022
Immune Disorder/Rare	St. Jude Children’s Research Hospital	Dr. Nichols	Repurposing a Blood Cancer Drug to Treat an Immune Disorder (HLH) in Children*	Drug	Pediatric	In Process
Infectious Disease	George Washington University, Universidad El Bosque	Dr. Chang	Repurposing a Flu Treatment for Severe Dengue Patients in Colombia	Drug	Pediatric	In Process
Infectious Disease	University of Chicago	Dr. Meltzer	Can Vitamin D Reduce the Burden of COVID-19 in Chicago?	Nutraceutical	Adult	In Process
Inflammatory Disease	SIDS Hospital and Research Centre	Dr. Mehta	Combining the Cholesterol-Lowering Drug Simvastatin with the N-Acetylcysteine for Chronic Pancreatitis in India	Drug	Adult	Started 2022
Liver Disease/Rare	Vietnam National Children’s Hospital/Big Leap Research	Dr. Nguyen	Improving Outcomes for the Rare Liver Disease Biliary Atresia with a Cancer Drug in Vietnam	Drug	Pediatric	In Process
Muscular Disorder/Rare	The Hospital for Sick Children, National Institutes of Health	Drs. Dowling, Bönnemann	TAM4MTM: Tamoxifen Therapy for Myotubular Myopathy	Drug	Pediatric	In Process
Neuro	University of California, Los Angeles	Dr. Ackerman	Testing a Repurposed Device to Improve the Treatment of Chronic Pelvic Pain in Women	Device	Adult	Started 2022
Neuro	The Pennsylvania State University and the Milton S. Hershey Medical Center	Dr. Elfar	Repurposing a Multiple Sclerosis Drug in Severe Limb Trauma*	Drug into Diagnostic	Adult	In Process
Neuro	University of New Mexico	Dr. Lewine	Repurposing N-Acetylcysteine to Reduce Oxidative Stress, an Important Factor in Traumatic Brain Injury	Drug	Adult	Started 2022
Neuro	Rush University Medical Center	Dr. Voigt-Zuwala	Enhancing Posttraumatic Stress Disorder Treatment for Veterans via Prebiotic Supplementation	Nutraceutical	Adult	In Process
Neuro/Rare	Georgetown University	Dr. Anderson	Using a Cancer Drug in Huntington's Disease	Drug	Adult	In Process
Neuro/Rare	McGovern Medical School at The University of Texas Health Science Center at Houston	Dr. Furr-Stimming	Treating Irritability in Huntington’s Disease with a Repurposed Neurological Drug	Drug	Adult	In Process
Oncology/Rare	University of Cambridge	Prof. Allen	Testing Two Generic Drugs to Improve Outcomes in Osteosarcoma, a Rare Bone Cancer	Drug	Pre-Clinical	In Process
Oncology/Rare	University of California, Irvine	Dr. Fleischman	Treating a Group of Rare Blood Cancers, Myeloproliferative Neoplasms, with N-Acetylcysteine*	Drug	Adult	In Process
Oncology/Rare	The University of Texas MD Anderson Cancer Center	Dr. Gordon	Enhancing Treatment Response in Recurrent/Metastatic Osteosarcoma with Hydroxychloroquine*	Drug	Pediatric	In Process
Oncology/Rare	Loyola University Medical Center	Dr. Liotta	Repurposing the Blood Pressure Drug Minoxidil for the Treatment of Recurrent Chemo-Resistant Ovarian Cancer	Drug	Adult	In Process
Oncology/Rare	University of Michigan	Dr. Pettit	Using a Skin Cancer Drug to Improve Current Treatment in a Rare Blood Cancer, Myelofibrosis	Drug	Adult	In Process
Oncology/Rare	University of Michigan	Dr. Phillips	Improving Patient Response in Mantle Cell Lymphoma with Venetoclax	Drug	Adult	In Process
Oncology/Rare	Children’s Hospital of Philadelphia	Dr. Seif	Preventing Relapse After Bone Marrow Transplant in Pediatric Acute Lymphoblastic Leukemia (ALL) with a Personalized Treatment	Drug	Pediatric	In Process
Oncology/Rare	University of Michigan	Dr. Swiecicki	Repurposing Old Drugs as New Therapies for Metastatic Thyroid Cancer*	Drug	Adult	In Process
Oncology/Rare	Massachusetts General Hospital/Harvard Medical School, VUmc Cancer Center Amsterdam	Drs. Tannous, Arrillaga-Romany, Kouwenhoven	A Novel Combination of Generic Chemotherapy Drugs to Treat Brain Cancer	Drug	Adult	In Process
Ophthalmic/Rare	University of California, Davis	Dr. Park	Repurposing Bone Marrow Stem Cell Therapy for Vision Loss Caused by Retinitis Pigmentosa	Other	Adult	In Process
Ophthalmic/Rare	University of Michigan	Dr. Zacks	Testing a Generic Malarial Drug in a Rare Ophthalmic Condition, Retinitis Pigmentosa	Drug	Adult	In Process
Other	KEMRI-Wellcome Trust Research Programme	Dr. Hamaluba	Testing the Safety of a Metal Poisoning Drug to Treat Snakebite in Kenya	Drug	Adult	In Process
Rare/Vascular	Stanford University	Dr. Teng	Treating Vascular Malformations Using the Cancer Drug Trametinib*	Drug	Pediatric	In Process

*CureAccelerator Live! winner