Cardio/Neuro | University of California San Francisco | Dr. Amorim | Testing the Epilepsy Drug Perampanel to Prevent Seizures After Cardiac Arrest Resuscitation * | Drug | Adult | Started 2023 |
Dermatology | University of Antananarivo | Dr. Rapelanoro Rabenja | Effect of methotrexate as a treatment for moderate to severe atopic dermatitis in Madagascar
| Drug | Adult | Started 2023 |
Ear Nose Throat | House Institute Foundation | Dr. Derebery - Researcher Spotlight available here | Reducing vertigo and hearing loss in Meniere’s disease by repurposing a common allergy drug | Drug | Adult | In Process |
Ear Nose Throat | ibs.GRANADA | Dr. Gallego-Martinez | Searching for Pharmacogenetic Targets in Meniere’s Disease Patients | Drug | Pre-Clinical | Started 2022 |
Ear Nose Throat | Dent Neurologic Institute | Dr. Zhang | Combining an anti-epileptic drug with an anti-anxiety drug to treat the inner ear disorder Meniere’s disease | Drug | Adult | In Process |
Ear Nose Throat | University Hospital of Munich | Dr. Zwergal | Identifying a Potential Biomarker and Repurposed Migraine Treatment in Meniere’s disease | Drug | Adult | Started 2022 |
Ear Nose Throat | University Hospital of Munich | Drs. Zwergal and Filippopulos | Treating Vestibular Neuritis Symptoms with a Thyroid Hormone
| Drug | Adult | Started 2024 |
Ear Nose Throat | University of Illinois Chicago | Drs. Lee and Perez | Treating Chronic Sinus Inflammation with a Probiotic Sinus Wash
| Nutraceutical | Adult | Started 2024 |
Ear Nose Throat | Yale University | Dr. Navaratnam | Investigating the Effects of Blocking Immune Disease Pathways in Meniere’s Disease
| Drug | Pre-Clinical | Started 2024 |
Ear Nose Throat/Infectious Disease/Rare | University of Utah | Dr. Rower - Researcher Spotlight available here | Repurposing the Antiviral Drug Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss | Drug | Pediatric | In Process |
Immune Disorder/Rare | Cincinnati Children's Hospital Medical Center | Dr. Abonia
- Researcher Spotlight available here | Repurposing a Rare Disease Treatment for the Immune Disorder Eosinophilic Esophagitis | Drug | Adult | Started 2022 |
Immune Disorder/Rare | St. Jude Children’s Research Hospital | Dr. Nichols | Repurposing a Blood Cancer Drug to Treat an Immune Disorder (HLH) in Children * | Drug | Pediatric | In Process |
Infectious Disease | George Washington University, Universidad El Bosque | Dr. Chang - Researcher Spotlight available here | Repurposing a Flu Treatment for Severe Dengue Patients in Colombia | Drug | Pediatric | In Process |
Infectious Disease | Université d'Abomey-Calavi | Dr. Johnson | Adding Beta-lactam Antibiotics to Shorten Buruli Ulcer Disease Therapy in Benin
| Drug | Pediatric / Adult | Started 2024 |
Infectious Disease | University of Chicago | Dr. Meltzer | Can Vitamin D Reduce the Burden of COVID-19 in Chicago? | Nutraceutical | Adult | In Process |
Infectious Disease/Rare | International Centre for Diarrhoeal Disease Research, Bangladesh | Dr. Mondal | Assessing Safety and Efficacy of Oral Ivermectin in Post Kala-azar Dermal Leishmaniasis Treatment | Drug | Adult | Started 2023 |
Inflammatory Disease | SIDS Hospital and Research Centre | Dr. Mehta - Researcher Spotlight available here | Combining the Cholesterol-Lowering Drug Simvastatin with N-Acetylcysteine for Chronic Pancreatitis in India | Drug | Adult | Started 2022 |
Liver Disease/Rare | Vietnam National Children’s Hospital/Big Leap Research | Dr. Nguyen | Improving Outcomes for the Rare Liver Disease Biliary Atresia with a Cancer Drug in Vietnam | Drug | Pediatric | In Process |
Maternal Health | Busitema University Faculty of Health Sciences | Dr. Musaba | Using Sodium Bicarbonate to Reduce Maternal / Fetal Death from Acidosis During Obstructed Labor
| Drug | Pediatric / Adult | Started 2024 |
Neuro | University of California, Los Angeles | Dr. Ackerman | Testing a Repurposed Device to Improve the Treatment of Chronic Pelvic Pain in Women | Device | Adult | Started 2022 |
Neuro | Edward Hines Jr VA Hospital and CARES | Dr. Bender Pape | Using an Approved Depression Treatment to Restore Cognitive Function in Veterans with Mild TBI and PTSD | Device | Adult | Started 2022 |
Neuro | Advocate Health Care | Dr. Burek | Testing a Low-Dose of the Hypertension Drug Clonidine for PTSD in Veterans | Drug | Adult | Started 2022 |
Neuro | Virginia Commonwealth University | Dr. Bjork | Daily Rotigotine Patch to Enhance Behavioral Therapy for Cocaine Use Disorder Recovery in Veterans
| Drug | Adult | Started 2024 |
Neuro | University of North Carolina at Chapel Hill | Dr. Linnstaedt | Estrogen to Prevent Chronic Pain and PTSD Following Sexual Assault | Drug | Adult | Started 2023 |
Neuro | University of Zambia | Dr. Zimba | Testing an Antihypertensive Drug as an Add-On Therapy for Drug-Resistant Epilepsy Patients in Zambia
| Drug | Adult | Started 2023 |
Neuro/Rare | Edward Hines Jr. VA Hospital and CARES | Dr. Kletzel | Improving cognitive function in Veterans with atypical parkinsonism with rTMS brain stimulation
| Device | Adult | Started 2024 |
Neuro/Infectious Disease | Emory University School of Medicine | Dr. McKenzie-Brown - Researcher Spotlight available here | Addressing Chronic Pain in HIV Patients with an Approved Addiction Treatment | Drug | Adult | Started 2022 |
Oncology | University of Pittsburgh | Dr. Davar | Reducing Immune-Related Adverse Events by Adding Oral FMT to Solid Tumor Cancer Treatment
| Other | Adult | Started 2024 |
Oncology | University of Illinois Chicago | Dr. Ibraheem | Using a Generic Drug Combination in Early-Stage Hormone Receptor Positive Breast Cancer Patients
| Drug | Adult | Started 2023 |
Oncology | University of Illinois Chicago | Dr. Reizine | Glycyrrhizin in Prostate Cancer: A Window-of-Opportunity Clinical Trial
| Nutraceutical | Adult | Started 2024 |
Oncology/Rare | University of California, Irvine | Dr. Fleischman - Researcher Spotlight available here | Treating a Group of Rare Blood Cancers, Myeloproliferative Neoplasms, with N-Acetylcysteine * | Drug | Adult | In Process |
Oncology/Rare | University of Michigan | Dr. Ghosh | Reducing CAR T-cell therapy complications in relapsed lymphoma patients by adding natalizumab
| Drug | Adult | Started 2023 |
Oncology/Rare | The University of Texas MD Anderson Cancer Center | Dr. Gordon
- Researcher Spotlight available here | Enhancing Treatment Response in Recurrent/Metastatic Osteosarcoma with Hydroxychloroquine * | Drug | Pediatric | In Process |
Oncology/Rare | Brown University / Rhode Island Hospital | Dr. Holder | Repurposing the Prostate Cancer Drug Degarelix to Treat Bladder Cancer * | Drug | Adult | Started 2023 |
Oncology/Rare | University of Pittsburgh | Dr. Ito | Investigating a Rare Disease Drug to Treat AML and MDS Patients with Post-Stem Cell Transplant Relapse | Drug | Adult | Started 2023 |
Oncology/Rare | Loyola University Medical Center | Dr. Liotta
- Researcher Spotlight available here | Repurposing the Blood Pressure Drug Minoxidil for the Treatment of Recurrent Chemo-Resistant Ovarian Cancer and Other Gynecological Cancers | Drug | Adult | In Process |
Oncology/Rare | Muhimbili University Health and Allied Sciences | Dr. Malichewe | Testing a Generic Drug Combination to Treat AML in Tanzania
| Drug | Adult | Started 2024 |
Oncology/Rare | University Hospital College Ibadan | Dr. Ntekim
- Researcher Spotlight available here | Adding the Antibiotic Clofazimine to Chemotherapy for Triple Negative Breast Cancer in Nigeria | Drug | Adult | Started 2022 |
Oncology/Rare | The University of Texas MD Anderson Cancer Center | Dr. Ohanian | Adding Metal Detoxification Drugs to Improve Childhood AML and Other Blood Cancer Outcomes | Drug | Pediatric | Started 2023 |
Oncology/Rare | City of Hope | Dr. Phillips - Researcher Spotlight available here | Repurposing Venetoclax and Glofitamab to Improve Patient Response in Mantle Cell Lymphoma | Drug | Adult | Started 2023 |
Oncology/Rare | University of Illinois Chicago | Dr. Sims - Researcher Spotlight available here | Repurposing a Diagnostic Device to Address Health Disparities in Esophageal Cancer Screening and Outcomes | Device / Diagostic | Adult | Started 2022 |
Oncology/Rare | Children’s Hospital of Philadelphia | Dr. Seif - Researcher Spotlight available here | Preventing Relapse After Bone Marrow Transplant in Pediatric Acute Lymphoblastic Leukemia (ALL) with a Personalized Treatment | Drug | Pediatric | In Process |
Oncology/Rare | Emory University School of Medicine | Dr. Romancik | Combining Approved Drugs for Alcoholism and Cancer to Treat Diffuse Large B-cell Lymphoma | Drug | Adult | Started 2023 |
Oncology/Rare | Brigham Young University | Dr. Watt | Treating Anemia in Myelofibrosis with Nelfinavir
| Drug | Adult | Started 2023 |
Oncology/Rare | Colorado State University | Dr. Regan | Evaluating an Approved Drug Combination Plus Immunotherapy in Canine Metastatic Osteosarcoma
| Drug | Pre-Clinical | Started 2023 |
Ophthalmic/Rare | University of Michigan | Dr. Zacks | Testing a Generic Malarial Drug in a Rare Ophthalmic Condition, Retinitis Pigmentosa | Drug | Adult | In Process |
Rare | Global Health Uganda Ltd | Dr. Namazzi | Adding Zinc to Reduce Sickle Cell Anemia-related Infections in Ugandan Children | Nutraceutical | Pediatric | Started 2024 |
Rare | University of Chicago | Dr. Wesevich | Testing a Low-Dose Anti-inflammatory Drug Tocilizumab for Acute Chest Syndrome in Sickle Cell Disease | Drug | Adult | Started 2023 |
Rare | Children's National Research Institute | Dr. Shur | Using Steroids to Improve Rhabdomyolysis Outcomes in Pediatric Patients | Drug | Pediatric | Started 2023 |
Rare/Vascular | Stanford University | Dr. Teng - Researcher Spotlight available here | Treating Vascular Malformations Using the Cancer Drug Trametinib * | Drug | Pediatric | In Process |