Repurposing Grants for the Rest of the World
ReGRoW is a non-profit program developed to support the growth of clinical research from within low and lower-middle income countries (LMICs) to find treatments for patients in LMICs, using repurposed therapies.
Funding For Clinical Research From Within LMICs
There is a significant need for expanding clinical research capacity in LMICs, where many talented researchers struggle to get the necessary funding to advance their ideas. Currently, less than 10% of global resources are dedicated to research in developing countries. We are addressing both the need for the building of clinical research capacity and the funding gap in LMICs with our program called ReGRoW: Repurposing Grants for the Rest of the World.
ReGRoW is providing four grants – between US$25,000 and US$50,000 each – for scientists and clinicians in LMICs who are investigating how currently approved therapies can be repurposed for the treatment of unsolved diseases in their own communities.
In doing so, we aim to:
- Expand the potential for and funding of clinical research in LMICs
- Address local health concerns through local research
- Empower scientists through funding access
- Lower the cost of clinical development by using therapies already known to be safe and effective in other indications
Cures Within Reach received over 30 proposal submissions from 12 LMIC countries on 4 continents. After a 2-stage review process, supported by our Science Advisory Board, over 20 volunteer, external members of our Grant Review Committee, and input from our ReGRoW funding partners, Cures Within Reach selected four clinical repurposing projects for funding during our pilot year:
Snakebite in Kenya:Testing the Safety of a Repurposed Drug to Treat Snakebite
Infectious disease in Nigeria: Treating Tuberculosis with a Lipid Lowering Drug
Infectious disease in Kenya: pending
Rare Pediatrics in Vietnam: pending
Cures Within Reach thanks Takeda Pharmaceuticals Research & Development Division for support in helping conceptualize the ReGRoW pilot as well as providing financial support of the initial ReGRoW projects, all in support of underserved communities and researchers.
Why Focus on Repurposed Therapies?
Developing, manufacturing, and gaining regulatory approval for a novel pharmaceutical can take up to 20 years, from bench to bedside. One strategy for shortening the drug development timeline is repurposing currently approved therapies for the treatment of unsolved diseases. This can drive the discovery of more treatments for more patients more quickly.
There are many advantages with repurposing approved drugs.
Repurposing Projects Funded
Startups with CWR Investments
Companies Commercializing CWR Projects
Millions of Dollars in Project Funding
Millions of Dollars in Follow-on Funding Leveraged
Eligibility Criteria for ReGRoW
Do you (or anyone you know!) have a clinical repurposing research idea that would be a good fit for ReGRoW?
To be eligible for a ReGRoW grant, proposed projects must:
- Serve an unmet medical need in any disease area (ReGRoW is disease-agnostic)
- Use only generic or off-patent drugs or drug-like compounds, including nutraceuticals and indigenous medicines, that can be accessed in the country where the research is being performed
- Involve only human clinical research
For principal investigators (PIs) to be eligible, their proposed research must be performed in institutions that:
- Are based in LMICs, according to criteria from the World Bank
- Have received previous external, third-party clinical research funding from a government, NGO, private foundation, or private source
- Have an Institutional Review Board, Ethics Committee or equivalent review board in place
- Follow the WHO’s GLP, GCLP, and/or GCP guidelines, or equivalent
- Have past or current experience with human clinical research
ReGRoW Proposal Submission Instructions
ReGRoW proposal submissions must be submitted through our CureAccelerator platform. CureAccelerator is free to use and acts as a forum for clinicians, researchers, patients and others to share and learn about repurposing research ideas. Sign up as a Researcher or Clinician today!
If you want to learn more about CureAccelerator, check out the CureAccelerator FAQ.
All proposals must be submitted on the CureAccelerator platform by 11:59 pm US Central Time on March 1, 2020, to be considered.
If you have eligibility or submission questions, or if you are interested in volunteering with ReGRoW, please contact Clare Thibodeaux, Ph.D. at firstname.lastname@example.org.
The Review Timeline
ReGRoW has a two-stage application process. The initial submission is a high-level proposal, and PIs are asked for basic information about the proposed treatment, research plan, budget, disease background, and other topics. Limited scientific details are required at the initial proposal stage, just enough to give reviewers a general sense of the research background and experimental plan. PIs will be notified by early April 2020 if their initial proposal has been selected to move on to the next stage of the process.
In the second stage, selected PIs will be invited to submit a full grant submission, which will include a detailed scientific plan and roadmap. PIs invited to submit a full grant will be provided with instructions and the necessary materials at that time, and will have approximately four weeks to complete the submission.
All PIs submitting a full grant may be invited to a showcase CureAccelerator Live! philanthropic pitch event to held in the future, likely virtually during CY2021 due to the ongoing COVID19 pandemic.
Do you know anyone who may be eligible to apply for a ReGRoW grant?
Do you know anyone who may want to volunteer for the ReGRoW pilot?
Do you want to stay up-to-date with announcements, reminders, and volunteer opportunities about the ReGRoW?
The ReGRoW pilot funds proof-of-concept clinical trials, of any design, that can determine whether or not a repurposed therapy may have a direct and positive impact on patients. We accept project proposals with budgets that are US$50,000 or less, or that have budgets greater than US$50,000 and have already received funding from other sources and are looking for additional funding sources.
More About Cures Within Reach
CWR improves patient quality and length of life by leveraging the speed, safety and cost-effectiveness of medical repurposing research, driving more treatments to more patients more quickly. We are a philanthropic leader in drug, device, and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Learn more by visiting: