Recently Completed Research

Recently Completed Repurposing Research


Recently completed repurposing researcher in the lab Recently completed repurposing research projects have been finished within the last three years. Funding the latest research supports clinicians and researchers across the country who are pursuing and discovering new indications for complex diseases.

We support repurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. Research projects are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research projects often include proof-of-concept clinical trials or other preclinical studies to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.

Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.

We follow completed repurposing research projects for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.

Completed in the last 5 years

Ear Nose ThroatCurtin UniversityDr. BrownTesting a generic diuretic to improve drug delivery to the inner ear in Meniere’s diseaseDrugPre-ClinicalCompleted 2021
Ear Nose ThroatStanford MedicineDrs. Grimes, Santa MariaModulating inner ear fluid regulation to treat Meniere’s diseaseDrugPre-ClinicalCompleted 2022
Ear Nose ThroatThe Feinstein Institutes for Medical ResearchDr. PathakInvestigating the effects of repurposed diuretic, steroid and immunosuppressive drugs in Meniere’s diseaseDrugPre-ClinicalCompleted 2023
NeuroUniversity of Pennsylvania MedicineDr. OathesUsing Imaging Techniques to Guide Targeted Brain Stimulation in the Treatment of Depression and Post-Traumatic Stress DisorderDeviceAdultCompleted 2021
GIOpenBiome, University of Cape TownDrs. Osman, BudreeThe THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa*OtherPediatricCompleted 2020
Infectious DiseaseNorthwestern UniversityDr. RadoRepurposing an Antidepressant to Prevent Hospitalization in COVID-19DrugAdultCompleted 2021
Infectious DiseaseObafemi Awolowo University & Teaching Hospitals ComplexDr. AdewoleTreating Tuberculosis with the Lipid Lowering Drug Atorvastatin in NigeriaDrugAdultCompleted 2022
Infectious Disease/GIBoston Children's HospitalDr. KahnFecal Microbiota Transplantation Patient Registry for Pediatric C-diffOtherPediatricCompleted 2021
OphthalmicUniversity of Pennsylvania MedicineDr. KimRepurposing a Nutraceutical to Treat a Type of Age-Related Macular DegenerationNutraceuticalAdultCompleted 2019
Liver Disease/RareChildren's National Health System, University of Illinois at ChicagoDr. Nadler, Dr. HoltermanUsing a Cancer Drug to Treat a Rare Pediatric Liver DiseaseDrugPediatricCompleted 2019
Metabolic Disorder/RareChildren's Hospital of Philadelphia, The Hospital for Sick ChildrenDrs. Levine, SochettRepurposing an Antibiotic to Treat a Defect in Vitamin D MetabolismDrugPediatricCompleted 2020
NeuroThe Pennsylvania State University and the Milton S. Hershey Medical CenterDr. ElfarRepurposing a Multiple Sclerosis Drug in Severe Limb Trauma*DrugAdultCompleted 2022
NeuroCincinnati Children's Hospital Medical CenterDr. WinkRepurposing a Generic Drug in Autism Spectrum DisorderDrugPediatricCompleted 2019
NeuroUniversity of TorontoDr. LanctôtA new opportunity to treat behavioral problems in Alzheimer’s patientsDrugAdultCompleted 2019
Neuro/RareGeorgetown UniversityDr. AndersonUsing a Cancer Drug in Huntington's Disease DrugAdultCompleted 2022
OncologyUniversity of ChicagoDrs. Chmura, BestvinaInnovations in Combination Therapies for Non-Small Cell Lung Cancer DrugAdultCompleted 2020
Oncology/RareJohns Hopkins MedicineDr. RigginsA Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic DrugDrugPediatricCompleted 2019
Oncology/RareUlm UniversityDr. HalatschCombining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer Drug AdultCompleted 2020
VascularUniversity of Illinois at ChicagoDrs. Havelka, Eton Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic*Drug/Device combo  AdultCompleted 2019

*CureAccelerator Live! winner