Recently Completed Research
Recently Completed Repurposing Research
Recently completed repurposing research trias have been finished within the last five years. Funding the latest research supports clinicians and researchers across the country who are pursuing and discovering new indications for complex diseases.
We support repurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. Research projects are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research projects often include proof-of-concept clinical trials or other preclinical studies to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.
Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.
We follow completed repurposing research trials for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.
Click HERE to see a map of our recently completed trials!
Completed in the last 5 years
DISEASE AREA | INSTITUTION | LEAD RESEARCHER | PROJECT NAME | TYPE | OTHER | STATUS |
---|---|---|---|---|---|---|
Diabetic Ophthalmology | Northwestern University | Dr. Basti | Treating Cataracts in Diabetic Patients Using a Surgical Device | Device | Adult | Completed 2023 |
Diabetes | Massachusetts General Hospital | Dr. Faustman | Repurposing a Vaccine for Type I Diabetes | Vaccine | Adult | Completed 2024 |
Ear Nose Throat | Curtin University | Dr. Brown | Testing a generic diuretic to improve drug delivery to the inner ear in Meniere’s disease | Drug | Pre-Clinical | Completed 2021 |
Ear Nose Throat | Stanford Medicine | Drs. Grimes, Santa Maria | Modulating inner ear fluid regulation to treat Meniere’s disease | Drug | Pre-Clinical | Completed 2022 |
Ear Nose Throat | The Feinstein Institutes for Medical Research | Dr. Pathak | Investigating the effects of repurposed diuretic, steroid and immunosuppressive drugs in Meniere’s disease | Drug | Pre-Clinical | Completed 2023 |
Ear Nose Throat | Medical University of South Carolina | Dr. Rizk | Assessing the efficacy of an antidepressant for improving vertigo attacks in Meniere’s disease | Drug | Adult | Completed 2023 |
Ear Nose Throat | University Hospital of Munich | Dr. Strupp - Researcher Spotlight available here | Combining a vertigo drug with a Parkinson’s disease drug to treat the inner ear disorder, Meniere’s disease | Drug | Adult | Completed 2023 |
Ear Nose Throat/Infectious Disease | University College Hospital Ibadan | Dr. Jatto - Researcher Spotlight available here | Repurposing a Widely Available Antiseptic in Pediatric Chronic Ear Infections in Nigeria | Drug | Pediatric | Completed 2023 |
GI | OpenBiome, University of Cape Town | Drs. Osman, Budree | The THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa * | Other | Pediatric | Completed 2020 |
Infectious Disease | Northwestern University | Dr. Rado | Repurposing an Antidepressant to Prevent Hospitalization in COVID-19 | Drug | Adult | Completed 2021 |
Infectious Disease | Obafemi Awolowo University & Teaching Hospitals Complex | Prof. Adewole - Researcher Spotlight available here | Treating Tuberculosis with the Lipid Lowering Drug Atorvastatin in Nigeria | Drug | Adult | Completed 2022 |
Infectious Disease/GI | Boston Children's Hospital | Dr. Kahn | Fecal Microbiota Transplantation Patient Registry for Pediatric C-diff | Other | Pediatric | Completed 2021 |
Liver Disease/Rare | Children's National Health System, University of Illinois at Chicago | Dr. Nadler, Dr. Holterman | Using a Cancer Drug to Treat a Rare Pediatric Liver Disease | Drug | Pediatric | Completed 2019 |
Metabolic Disorder/Rare | Children's Hospital of Philadelphia, The Hospital for Sick Children | Drs. Levine, Sochett - Researcher Spotlight available here | Repurposing an Antibiotic to Treat a Defect in Vitamin D Metabolism | Drug | Pediatric | Completed 2020 |
Neuro | University of Pennsylvania Medicine | Dr. Oathes | Using Imaging Techniques to Guide Targeted Brain Stimulation in the Treatment of Depression and Post-Traumatic Stress Disorder | Device | Adult | Completed 2021 |
Neuro/Rare | McGovern Medical School at The University of Texas Health Science Center at Houston | Dr. Furr-Stimming - Researcher Spotlight available here | Treating Irritability in Huntington’s Disease with a Repurposed Neurological Drug | Drug | Adult | Completed 2023 |
Neuro | The Pennsylvania State University and the Milton S. Hershey Medical Center | Dr. Elfar - Researcher Spotlight available here | Repurposing a Multiple Sclerosis Drug in Severe Limb Trauma* | Drug | Adult | Completed 2022 |
Neuro | Cincinnati Children's Hospital Medical Center | Dr. Wink | Repurposing a Generic Drug in Autism Spectrum Disorder | Drug | Pediatric | Completed 2019 |
Neuro | University of Toronto | Dr. Lanctôt - Researcher Spotlight available here | A new opportunity to treat behavioral problems in Alzheimer’s patients | Drug | Adult | Completed 2019 |
Neuro | University of New Mexico | Dr. Lewine - Researcher Spotlight available here | Repurposing N-Acetylcysteine to Reduce Oxidative Stress, an Important Factor in Traumatic Brain Injury | Drug | Adult | Completed 2023 |
Neuro | Rush University Medical Center | Dr. Voigt-Zuwala | Enhancing Posttraumatic Stress Disorder Treatment for Veterans via Prebiotic Supplementation | Nutraceutical | Adult | Completed 2024 |
Neuro/Rare | Georgetown University | Dr. Anderson | Using a Cancer Drug in Huntington's Disease | Drug | Adult | Completed 2022 |
Oncology | University of Chicago | Drs. Chmura, Bestvina | Innovations in Combination Therapies for Non-Small Cell Lung Cancer | Drug | Adult | Completed 2020 |
Oncology/Rare | Johns Hopkins Medicine | Dr. Riggins | A Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic Drug | Drug | Pediatric | Completed 2019 |
Oncology/Rare | University of Michigan | Dr. Swiecicki | Repurposing Old Drugs as New Therapies for Metastatic Thyroid Cancer* | Drug | Adult | Completed 2024 |
Oncology/Rare/Neuro | Massachusetts General Hospital/Harvard Medical School, VUmc Cancer Center Amsterdam | Dr. Tannous | A Novel Combination of Generic Chemotherapy Drugs to Treat Brain Cancer | Drug | Adult | Completed 2023 |
Oncology/Rare | Ulm University | Dr. Halatsch | Combining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer | Drug | Adult | Completed 2020 |
Ophthalmic | University of Pennsylvania Medicine | Dr. Kim | Repurposing a Nutraceutical to Treat a Type of Age-Related Macular Degeneration | Nutraceutical | Adult | Completed 2019 |
Ophthalmic/Rare | University of California, Davis | Dr. Park - Researcher Spotlight available here | Repurposing Bone Marrow Stem Cell Therapy for Vision Loss Caused by Retinitis Pigmentosa | Other | Adult | Completed 2023 |
Other | KEMRI-Wellcome Trust Research Programme | Dr. Hamaluba - Researcher Spotlight available here | Testing the Safety of a Metal Poisoning Drug to Treat Snakebite in Kenya | Drug | Adult | Completed 2023 |
Vascular | University of Illinois at Chicago | Drs. Havelka, Eton | Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic* | Drug/Device combo | Adult | Completed 2019 |
*CureAccelerator Live! winner