Recently Completed Research

Recently Completed Repurposing Research

 

Recently completed repurposing researcher in the lab Recently completed repurposing research projects have been finished within the last two years. Funding the latest research supports clinicians and researchers across the country who are pursuing and discovering new indications for complex diseases.

We support repurpurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and  rare diseases in pediatrics and adults. Research projects are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research projects often include proof-of-concept clinical trials or other preclinical studies to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.

Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.

We follow completed repurposing research projects for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.

Completed in the last 3 years

DISEASE AREAINSTITUTIONLEAD RESEARCHERPROJECT NAMETYPEOTHERSTATUS
CardioVanderbilt University Medical CenterDr. CoxComparison of Diuretic Combination Therapies in Heart Failure PatientsDrugAdultCompleted 2018
NeuroCincinnati Children's Hospital Medical CenterDr. WinkRepurposing a Generic Drug in Autism Spectrum DisorderDrugPediatricCompleted 2019
NeuroJohns Hopkins MedicineDr. HollingerRepurposing a Generic Drug in the Treatment of Pediatric Depression
DevicePediatricCompleted 2018
NeuroWeill Cornell Medical CollegeDr. Crystal Repurposing Gene Therapy for Batten DiseaseOtherPediatricCompleted 2018
NeuroUniversity of TorontoDr. LanctôtA new opportunity to treat behavioral problems in Alzheimer’s patientsDrugAdultCompleted 2019
NeuroRush University Medical CenterDr. Young, Dr. FitzgeraldRepurposing a Device to Treat Abnormalities of Gait and Balance in CNS disorders
 DeviceAdultCompleted 2018
OncologyRush University Medical CenterDr. BorgiaRepurposing a blood test to improve outcomes for high-risk lung cancer patients undergoing low-dose CT screeningDiagnosticAdultCompleted 2018
OncologySeattle ChildrensDr. Leary Drugs for Recurrent Pediatric Brain Tumors Drug Pediatric Completed 2018
OncologyVirginia Tech UniversityDr. DavalosUsing an Approved Device to Increase the Immune Response in Pancreatic Cancer Patients Device AdultCompleted 2018
OncologyUniversity of ChicagoDrs. Chmura, BestvinaInnovations in Combination Therapies for Non-Small Cell Lung Cancer DrugAdultCompleted 2020
Oncology / RareJohns Hopkins MedicineDr. RigginsA Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic DrugDrugPediatricCompleted 2019
Oncology/RareUlm UniversityDr. HalatschCombining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer Drug AdultCompleted 2020
OphthalmicUniversity of Pennsylvania MedicineDr. KimRepurposing a Nutraceutical to Treat a Type of Age-Related Macular DegenerationNutraceuticalAdultCompleted 2019
RareChildren's Hospital of Philadelphia, The Hospital for Sick ChildrenDrs. Levine, SochettRepurposing an Antibiotic to Treat a Defect in Vitamin D MetabolismDrugPediatricCompleted 2020
RareChildren's National Health System, University of Illinois at ChicagoDr. Nadler, Dr. HoltermanUsing a Cancer Drug to Treat a Rare Pediatric Liver DiseaseDrugPediatricCompleted 2019
VascularUniversity of Illinois at ChicagoDr. Havelka, Dr. Eton Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic*Drug/Device combo  AdultCompleted 2019