Recently Completed Research

Recently Completed Repurposing Research

 

Recently completed repurposing researcher in the lab We follow our completed repurposing research trials for up to five years. Our funding supports clinicians and researchers across the country and beyond who are pursuing and discovering new treatments for unsolved diseases.

We support repurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. Research trials are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research trials include proof-of-concept clinical trials to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.

Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.

We follow completed repurposing research trials for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.

Click HERE to see a map of our recently completed trials!

 

Recently Completed

DISEASE AREAINSTITUTIONLEAD RESEARCHERPROJECT NAMETYPEOTHERSTATUS
AutoimmuneMassachusetts General HospitalDr. FaustmanRepurposing a Vaccine for Type I DiabetesVaccineAdultCompleted 2024
Diabetic OphthalmologyNorthwestern UniversityDr. BastiTreating Cataracts in Diabetic Patients Using a Surgical DeviceDeviceAdultCompleted 2023
Ear Nose ThroatCurtin UniversityDr. BrownTesting a Generic Diuretic to Improve Drug Delivery to the Inner Ear in Meniere’s DiseaseDrugPre-ClinicalCompleted 2021
Ear Nose ThroatHouse Institute FoundationDr. Derebery - Researcher Spotlight available hereReducing Vertigo and Hearing Loss in Meniere’s Disease by Repurposing a Common Allergy DrugDrugAdultCompleted 2026
Ear Nose ThroatStanford MedicineDrs. Grimes, Santa MariaModulating Inner Ear Fluid Regulation to Treat Meniere’s DiseaseDrugPre-ClinicalCompleted 2022
Ear Nose ThroatThe Feinstein Institutes for Medical ResearchDr. PathakInvestigating the Effects of Repurposed Diuretic, Steroid and Immunosuppressive Drugs in Meniere’s DiseaseDrugPre-ClinicalCompleted 2023
Ear Nose ThroatMedical University of South CarolinaDr. Rizk
- Researcher Spotlight available here
Assessing the Efficacy of an Antidepressant for Improving Vertigo Attacks in Meniere’s DiseaseDrugAdultCompleted 2023
Ear Nose ThroatUniversity Hospital of MunichDr. Strupp - Researcher Spotlight available hereCombining a Vertigo Drug with a Parkinson’s Disease Drug to Treat the Inner Ear Disorder, Meniere’s DiseaseDrugAdultCompleted 2023
Ear Nose ThroatDent Neurologic Institute Dr. Zhang - Researcher Spotlight available hereCombining an Anti-Epileptic Drug with an Anti-Anxiety Drug to Treat the Inner Ear Disorder Meniere’s DiseaseDrugAdultCompleted 2024
Ear Nose Throatibs.GRANADA Dr. Gallego-MartinezSearching for Pharmacogenetic Targets in Meniere’s Disease PatientsDiagnosticPre-ClinicalCompleted 2024
Ear Nose ThroatUniversity Hospital of MunichDr. ZwergalIdentifying a Potential Biomarker and Repurposed Migraine Treatment in Meniere’s diseaseDrugAdultCompleted 2025
Ear Nose Throat/Infectious DiseaseUniversity College Hospital IbadanDr. Jatto
- Researcher Spotlight available here
Repurposing a Widely Available Antiseptic in Pediatric Chronic Ear Infections in Nigeria DrugPediatricCompleted 2023
Ear Nose Throat/Infectious Disease/RareUniversity of UtahDr. Rower - Researcher Spotlight available hereRepurposing the Antiviral Drug Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss DrugPediatricCompleted 2024
GIOpenBiome, University of Cape TownDrs. Osman, BudreeThe THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa *OtherPediatricCompleted 2020
Immune Disorder/RareSt. Jude Children’s Research HospitalDr. Nichols - Researcher Spotlight available hereRepurposing a Blood Cancer Drug to Treat an Immune Disorder (HLH) in Children *DrugPediatricCompleted 2025
Infectious DiseaseUniversity of ChicagoDr. Meltzer - Researcher Spotlight available hereCan Vitamin D Reduce the Burden of COVID-19 in Chicago?NutraceuticalAdultCompleted 2025
Infectious DiseaseNorthwestern UniversityDr. RadoRepurposing an Antidepressant to Prevent Hospitalization in COVID-19DrugAdultCompleted 2021
Infectious DiseaseObafemi Awolowo University & Teaching Hospitals ComplexProf. Adewole
- Researcher Spotlight available here
Treating Tuberculosis with the Lipid Lowering Drug Atorvastatin in NigeriaDrugAdultCompleted 2022
Infectious Disease/GIBoston Children's HospitalDr. KahnFecal Microbiota Transplantation Patient Registry for Pediatric C-diffOtherPediatricCompleted 2021
Infectious Disease/RareInternational Centre for Diarrhoeal Disease Research, BangladeshDr. Mondal - Researcher Spotlight available hereAssessing Safety and Efficacy of Oral Ivermectin in Post Kala-azar Dermal Leishmaniasis TreatmentDrugAdultCompleted 2025
Inherited DisorderGlobal Health Uganda LtdDr. NamazziAdding Zinc to Reduce Sickle Cell Anemia-related Infections in Ugandan ChildrenNutraceuticalPediatricCompleted 2025
Inflammatory DiseaseSIDS Hospital and Research CentreDr. Mehta - Researcher Spotlight available hereCombining the Cholesterol-Lowering Drug Simvastatin with N-Acetylcysteine for Chronic Pancreatitis in IndiaDrugAdultCompleted 2025
Liver Disease/RareChildren's National Health System, University of Illinois at ChicagoDr. Nadler, Dr. HoltermanUsing a Cancer Drug to Treat a Rare Pediatric Liver DiseaseDrugPediatricCompleted 2019
Metabolic Disorder/RareChildren's Hospital of Philadelphia, The Hospital for Sick ChildrenDrs. Levine, Sochett
- Researcher Spotlight available here
Repurposing an Antibiotic to Treat a Defect in Vitamin D MetabolismDrugPediatricCompleted 2020
NeuroUniversity of Pennsylvania MedicineDr. Oathes - Researcher Spotlight available hereUsing Imaging Techniques to Guide Targeted Brain Stimulation in the Treatment of Depression and Post-Traumatic Stress DisorderDeviceAdultCompleted 2021
Neuro/RareMcGovern Medical School at The University of Texas Health Science Center at HoustonDr. Furr-Stimming - Researcher Spotlight available hereTreating Irritability in Huntington’s Disease with a Repurposed Neurological DrugDrugAdultCompleted 2023
NeuroThe Pennsylvania State University and the Milton S. Hershey Medical CenterDr. Elfar
- Researcher Spotlight available here
Repurposing a Multiple Sclerosis Drug in Severe Limb Trauma*DrugAdultCompleted 2022
NeuroCincinnati Children's Hospital Medical CenterDr. WinkRepurposing a Generic Drug in Autism Spectrum DisorderDrugPediatricCompleted 2019
NeuroSunnybrook Research InstituteDr. Lanctôt - Researcher Spotlight available hereA New Opportunity to Treat Behavioral Problems in Alzheimer’s PatientsDrugAdultCompleted 2019
NeuroUniversity of New MexicoDr. Lewine - Researcher Spotlight available hereRepurposing N-Acetylcysteine to Reduce Oxidative Stress, an Important Factor in Traumatic Brain InjuryDrugAdultCompleted 2023
NeuroRush University Medical CenterDr. Voigt-Zuwala - Researcher Spotlight available hereEnhancing PTSD Treatment for Veterans via Prebiotic SupplementationNutraceuticalAdultCompleted 2024
NeuroUniversity of California, Los AngelesDr. AckermanTesting a Repurposed Device to Improve the Treatment of Chronic Pelvic Pain in WomenDeviceAdultCompleted 2025
NeuroUniversity of ZambiaDr. Zimba
- Researcher Spotlight available here
Testing an Antihypertensive Drug as an Add-On Therapy for Drug-Resistant Epilepsy Patients in Zambia
DrugAdultCompleted 2025
Neuro/RareGeorgetown UniversityDr. AndersonUsing a Cancer Drug in Huntington's Disease DrugAdultCompleted 2022
OncologyUniversity of ChicagoDrs. Chmura, BestvinaInnovations in Combination Therapies for Non-Small Cell Lung Cancer DrugAdultCompleted 2020
Oncology/RareColorado State UniversityDr. ReganEvaluating an Approved Drug Combination Plus Immunotherapy in Canine Metastatic Osteosarcoma
DrugPre-ClinicalCompleted 2026
Oncology/RareJohns Hopkins MedicineDr. RigginsA Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic DrugDrugPediatricCompleted 2019
Oncology/RareUniversity of MichiganDr. SwiecickiRepurposing Old Drugs as New Therapies for Metastatic Thyroid Cancer*DrugAdultCompleted 2024
Oncology/RareUniversity of Illinois ChicagoDr. Sims - Researcher Spotlight available hereRepurposing a Diagnostic Device to Address Health Disparities in Esophageal Cancer Screening and OutcomesDevice / DiagosticAdultCompleted 2025
Oncology/RareThe University of Texas MD Anderson Cancer CenterDr. Gordon
- Researcher Spotlight available here
Enhancing Treatment Response in Recurrent/Metastatic Osteosarcoma with Hydroxychloroquine *DrugPediatricCompleted 2025
Oncology/RareUniversity of PittsburghDr. Ito - Researcher Spotlight available hereInvestigating a Rare Disease Drug to Treat AML and MDS Patients with Post-Stem Cell Transplant RelapseDrugAdultCompleted 2025
Oncology/Rare/NeuroMassachusetts General Hospital/Harvard Medical School, VUmc Cancer Center AmsterdamDr. TannousA Novel Combination of Generic Chemotherapy Drugs to Treat Brain CancerDrugAdultCompleted 2023
Oncology/RareUlm UniversityDr. HalatschCombining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer Drug AdultCompleted 2020
OphthalmicUniversity of Pennsylvania MedicineDr. KimRepurposing a Nutraceutical to Treat a Type of Age-Related Macular DegenerationNutraceuticalAdultCompleted 2019
Ophthalmic/Rare/Inherited DisorderUniversity of California, DavisDr. Park - Researcher Spotlight available hereRepurposing Bone Marrow Stem Cell Therapy for Vision Loss Caused by Retinitis Pigmentosa OtherAdultCompleted 2023
Ophthalmic/Rare/Inherited DisorderUniversity of MichiganDr. ZacksTesting a Generic Malarial Drug in a Rare Ophthalmic Condition, Retinitis Pigmentosa DrugAdultCompleted 2024
OtherKEMRI-Wellcome Trust Research ProgrammeDr. Hamaluba
- Researcher Spotlight available here
Testing the Safety of a Metal Poisoning Drug to Treat Snakebite in KenyaDrugAdultCompleted 2023
VascularUniversity of Illinois at ChicagoDrs. Havelka, Eton Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic*Drug/Device combo  AdultCompleted 2019
Vascular/RareStanford UniversityDr. Teng - Researcher Spotlight available hereTreating Vascular Malformations Using the Cancer Drug Trametinib *DrugPediatricCompleted 2025

*CureAccelerator Live! winner