Recently Completed Research
Recently Completed Repurposing Research
Recently completed repurposing research projects have been finished within the last three years. Funding the latest research supports clinicians and researchers across the country who are pursuing and discovering new indications for complex diseases.
We support repurpurposing research for any and all disease areas including cardio, neuro, oncology, ophthalmic, vascular and rare diseases in pediatrics and adults. Research projects are dedicated to repurposing approved drugs, devices, diagnostics, nutraceuticals and combination products. Recently completed repurposing research projects often include proof-of-concept clinical trials or other preclinical studies to evaluate the efficacy and appropriate uses for repurposing. Successful researchers often leverage positive data into follow-on funding.
Our impact philanthropy approach prioritizes the patient. Our funding helps complete repurposing research for philanthropic projects which have critical value and impact on patients, but little or no commercial value. We also fund commercial repurposing projects. This may result in industry bringing these projects to regulatory approval and then to market. Patients benefit from having additional treatment options.
We follow completed repurposing research projects for up to 5 years measuring our funding’s patient and scientific impact in many ways, including a) the leverage of positive data into follow-on funding; b) papers published or presented; c) larger clinical trials conducted; and d) positive patient outcomes.
Completed in the last 3 years
|DISEASE AREA||INSTITUTION||LEAD RESEARCHER||PROJECT NAME||TYPE||OTHER||STATUS|
|Ear Nose Throat||Curtin University||Dr. Brown||Testing a generic diuretic to improve drug delivery to the inner ear in Meniere’s disease||Drug||Pre-Clinical||Completed 2021|
|GI||OpenBiome, University of Cape Town||Drs. Osman, Budree||The THRIVE Study: Repurposing Fecal Microbiota Transplantation for the Treatment of Pediatric Malnutrition in South Africa*||Other||Pediatric||Completed 2020|
|Infectious Disease||Northwestern University||Dr. Rado||Repurposing an Antidepressant to Prevent Hospitalization in COVID-19||Drug||Adult||Completed 2021|
|Infectious Disease||Obafemi Awolowo University & Teaching Hospitals Complex||Dr. Adewole||Treating Tuberculosis with the Lipid Lowering Drug Atorvastatin in Nigeria||Drug||Adult||Completed 2022|
|Infectious Disease/GI||Boston Children's Hospital||Dr. Kahn||Fecal Microbiota Transplantation Patient Registry for Pediatric C-diff||Other||Pediatric||Completed 2021|
|Liver Disease/Rare||Children's National Health System, University of Illinois at Chicago||Dr. Nadler, Dr. Holterman||Using a Cancer Drug to Treat a Rare Pediatric Liver Disease||Drug||Pediatric||Completed 2019|
|Metabolic Disorder/Rare||Children's Hospital of Philadelphia, The Hospital for Sick Children||Drs. Levine, Sochett||Repurposing an Antibiotic to Treat a Defect in Vitamin D Metabolism||Drug||Pediatric||Completed 2020|
|Neuro||Cincinnati Children's Hospital Medical Center||Dr. Wink||Repurposing a Generic Drug in Autism Spectrum Disorder||Drug||Pediatric||Completed 2019|
|Neuro||University of Pennsylvania Medicine||Dr. Oathes||Using Imaging Techniques to Guide Targeted Brain Stimulation in the Treatment of Depression and Post-Traumatic Stress Disorder||Device||Adult||Completed 2021|
|Neuro||University of Toronto||Dr. Lanctôt||A new opportunity to treat behavioral problems in Alzheimer’s patients||Drug||Adult||Completed 2019|
|Oncology||University of Chicago||Drs. Chmura, Bestvina||Innovations in Combination Therapies for Non-Small Cell Lung Cancer||Drug||Adult||Completed 2020|
|Oncology/Rare||Johns Hopkins Medicine||Dr. Riggins||A Phase I Trial for Recurrent Pediatric Brain Cancers Using a Repurposed Generic Drug||Drug||Pediatric||Completed 2019|
|Oncology/Rare||Ulm University||Dr. Halatsch||Combining Nine Repurposed Drugs with a Current Chemotherapy Treatment in Adult Brain Cancer||Drug||Adult||Completed 2020|
|Ophthalmic||University of Pennsylvania Medicine||Dr. Kim||Repurposing a Nutraceutical to Treat a Type of Age-Related Macular Degeneration||Nutraceutical||Adult||Completed 2019|
|Vascular||University of Illinois at Chicago||Dr. Havelka, Dr. Eton||Saving Limbs from Chronic Ischemia: Helping Nature Do Its Magic*||Drug/Device combo||Adult||Completed 2019|
*CureAccelerator Live! winner