Improving Cognitive Function in Veterans with Atypical Parkinsonism with rTMS Brain Stimulation

Principal Investigator: Dr. Sandra Kletzel

Disease: Atypical Parkinsonism

Research Description: Atypical parkinsonisms (APs) represent a group of progressive nervous system disorders such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and Lewy Body Dementia. APs are similar to Parkinson’s disease (PD), as both AP and PD affect movement and many other behaviors, including cognition. However, dementia in AP patients may be more severe and occur earlier in the disease course than in PD. Current medication does not improve this cognitive decline, which negatively impacts the quality of life for AP patients. The research team is expanding an ongoing Veterans Administration-funded, multi-arm, randomized, placebo-controlled clinical trial testing repetitive Transcranial Magnetic Stimulation (rTMS), approved to treat depression and obsessive-compulsive disorder, for the treatment of cognitive impairment in veterans with PD by adding an arm of veterans diagnosed with AP. If successful, rTMS treatment could improve thinking, memory and quality of life for AP patients, thereby increasing safe and independent living and lowering the medical system burden.

Funding Partners: The Searle Funds at The Chicago Community Trust, The Kahlert Foundation, Westlake Health Foundation, and others

CWR Funding Role: Participating